Mbed Pathology

Mbed Pathology collaborates with, supports and serves the needs of scientists, post doctoral fellows, graduate students and research staff using animals in their research by providing the services of a board certified veterinary pathologist trained to identify and interpret gross and histologic lesions in laboratory species. Information gleaned from gross and histologic examination can be used in systematically phenotyping genetically modified mice, identifying and guiding the development of animal models of human disease, and determining the cause of unexpected death in research animals. We provide on-site consultation and training in veterinary pathology procedures, including comprehensive necropsy, tissue collection, and tissue fixation.

 

D Meegan Larsen BA, DVM, DVSc, DACVP

Dr. Larsen graduated magna cum laude from Dartmouth College in 1995 with a Bachelor's Degree in Environmental and Evolutionary Biology and obtained her Doctor of Veterinary Medicine from the Ontario Veterinary College at the University of Guelph in 2000.

After working as a clinical veterinarian at a small and exotic companion animal hospital in Toronto, she pursued her interest in research at Stanford University, working as a research associate. As a member of the Goodman and Robinson labs, she developed surgical mouse models of osteoarthritis and orthopedic implant failure, and gained experience in mouse colony management.

In 2008, Dr. Larsen returned to the Ontario Veterinary College as a graduate student in Anatomic Pathology, graduating with a Doctor of Veterinary Science in 2012. Working with Dr. Geoffrey Wood, she investigated molecular markers of malignancy in canine osteosarcoma and identified PRKAR1-alpha as a relevant prognostic factor.

After a subsequent year of diagnostic pathology training as a senior resident at the New York State Veterinary Diagnostic Laboratory at Cornell University, Dr. Larsen became a diplomate of the American College of Veterinary Pathologists in 2013.

Selected Publications

1.  Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen K, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW. Cancer Cell (2016) 30(2):337-48.

2.  Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice. Hao Z, Cairns RA, Inoue S, Li WY, Sheng Y, Lemonnier F, Wakeham A, Snow BE, Dominguez-Brauer C, Ye J, Larsen DM, Straley KS, Tobin ER, Narayanaswamy R, Gaulard P, Mak TW. Proc Natl Acad Sci U S A. (2016) 113(5):1387-92.

3. Cholesteatoma and meningoencephalitis in a dog with chronic otitis externa. Newman AW, Estey CM, McDonough S, Cerda-Gonzalez S, Larsen M, Stokol T. Vet Clin Pathol. (2015) 44(1):157-63.

4.  Identification of a central role for complement in osteoarthritis.  Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH.  Nat Med (2011) 17(12):1674-9.

5.  Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo.  Ma T, Ren PG, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB.  J Biomed Mater Res A (2009) 89(1):117-23.

6.  Mouse femoral intramedullary injection model: Technique and microCT scan validation. Zilber S, Epstein NJ, Lee SW, Larsen M, Ma T, Smith RL, Biswal S, Goodman SB.  J Biomed Mater Res B Appl Biomater (2008) 84(1):286-90. 

7.  Modulation of allograft incorporation by continuous infusion of growth factors over a prolonged duration in vivo.  Ma T, Gutnick J, Salazar B, Larsen MD, Suenega E, Zilber S, Huang Z, Huddleston J, Smith RL, Goodman S. Bone (2007) 41(3):386-92.

8.  Effects of local infusion of OP-1 on particle-induced and NSAID-induced inhibition of bone ingrowth in vivo.  Ma T, Nelson ER, Mawatari T, Oh K, Larsen DM, Smith RL, Goodman SB.  J Biomed Mater Res A (2006) 79(3):740-6.